Kacy Catanzaro: the first woman in American Ninja Warrior history to qualify for Mt. Midoriyama.
EDIT: Thanks to this anon, I’ve been informed that Ayako Miyake was the first woman to qualify and finish the Female Japanese Ninja Warrior three times. While it’s not the same course, she’s another equally incredible woman performing a difficult feat.
EDIT 2: Thanks tomminorsetbackk, I’ve also been told that Chie Tanabe completed the first stage in Sasuke and attempted the second.